March 3rd, 2020, Journal of Zhejiang University(Medical Sciences)
A pilot study of hydroxychloroquine in treatment of patients with common coronavirus disease-19 (COVID-19)
Observation study of 30 patients by Fudan University, Shanghai, given HCQ. Published March 6th
.
As of 26th March
.
Joint French & Vietnamese Study
An observational study of 80 patients using a combination of HydroxyChlorquine & Azithromycin with a 6 day followup
.
Azithromycin is an antibiotic (ie for bacteria, not viruses. Covid-19 is a virus). It was unethically peer reviewed by Jean-Marc Roulaine within 24 hours of submission and then printed in the journal
which Roulaine is the editor-in-chief of (as pointed out in the blog below) and another author is his boss at the Research Unit in Infectious and Tropical Emergent Diseases (URMITE) in Marseille:
Didier Raolut.
There have been two secondary analyses of the above:
- Andrew Lover from Uni of Mass. Amherst
dismisses the study as "insufficient".
- Elisabeth Bik's blog
debunks
it by identifying a conflict of interest and flawed methodology.
March 28th 2020, Paris, Médecine et Maladies Infectieuses.
No Evidence of Rapid Antiviral Clearance or Clinical Benefit with the Combination of Hydroxychloroquine and Azithromycin in Patients with Severe COVID-19 Infection
Reddit discussion: "Study of 11 people, many with severe comorbidities including cancer and HIV."
March 29th 2020, American College of Cardiology.
Simpson (San Francisco), Kovacs (Indiana), Stecker (Oregon)
Ventricular Arrhythmia Risk Due to Hydroxychloroquine-Azithromycin
April 2nd 2020, Medrxiv (PrePrint)
The QT Interval in Patients with SARS-CoV-2 Infection Treated with Hydroxychloroquine/Azithromycin.
"This is a retrospective study performed at
NYU Langone medical center, New York.
We reviewed 84 consecutive adult patients who were hospitalized
at NYULangone medical center
with a positive SARS-CoV-2 disease
and were treated with the combination of HY/AZ."
Wikipedia says
"An abnormally long or abnormally short QT interval is associated with an increased risk of developing abnormal heart rhythms and sudden cardiac death."
Peer Reviewed, April 29th 2020 in American Heart Association
New York
The QT Interval in Patients with SARS-CoV-2 Infection Treated with Hydroxychloroquine/Azithromycin.
Same conclusion as Chorin et al. earlier that month.
May 7th 2020, New York City
Funded by the National Institutes of Health
Large observational study of 811 HCQ treated patients (vs 565 without HCQ)
HCQ "not associated with either a greatly lowered or
an increased risk of the composite end point of
intubation
or death.
Randomized, controlled trials... are needed."
Reddit discussion.
Preprent April 10th 2020 in MedRxiv
Sherbroooke University, Canada
May 8th 2020, New York City
NYU Grossman School of Medicine
Preprint study of 450 HCQ+AZ+ZN treated patients (vs 450 with just HCQ+AZ)
HCQ = HydroxyChloroquine
AZ = antibiotic azithromycin
ZN = zinc
The triple-drug combo group had a 1.5 times greater probability of getting better.
They were also more likely to eventually be discharged from the hospital
compared to those who were only given the double-drug combination.
It is possible ZN was simply countering negative effects of HCQ+AZ.
Controlled trials needed.
Reddit discussion.
May 14th 2020, Paris
Henri-Mondor Hospital
Observational study of 84 HCQ treated patients who needed oxygen (vs 97 without HCQ)
Treatment did not significantly reduce admission to intensive care or death within seven days,
or the development of acute respiratory distress syndrome within 10 days.
Reddit discussion.
Appeared May 6th 2020 at PrePrints.org
"Enrolled all adult inpatients from Central Defense Hospital “Gómez Ulla”, Madrid, Spain, who were hospitalised
for COVID-19 infection and had a definitive outcome (either dead or discharged)."
Comment from Frank Conijn:
the no-HCQ group probably just was a lot sicker than the HCQ group. Which invalidates [the] conclusion [that HCQ increases survival].
May 14th 2020, Shanghai
Jiao Tong University School of Medicine
Randomised controlled study of 75 adults hospitalized with mainly mild or moderate COVID-19 (vs 75 without)
Treatment did not significantly reduce admission to intensive care or death within seven days.
HCQ patients experienced more adverse events.
There was little difference in reduction of symptoms and time to relief of symptoms
between the two groups of patients.
Reddit discussion.
Go to Covidiocracy "Myths" section
"Recently, the Chinese Government
included [CQ]... for the treatment of novel coronavirus pneumonia".
France endorses use but only for "serious" cases while they wait two weeks for results of French trials.
Pre-print meta-analysis by two Kathmandu academics says HCQ & CQ have potential but corroborating evidence from studies is needed.
Trump is pushing
for both Hydroxy-Chloroquine and Chloroquine in USA, green-lighting any doctor to prescribe them "off-label". Bitter
in-fighting
ensues in the
White House.
Aussie mining magnate Clive Palmer is funding ads claiming it is a cure for Covd-19.
This claim is being
legally investigated
by the TGA
(As a mining magnate
he is no stranger to legal action
and was leader of his own minor political party which has been disproportionately influential.
Three people in Nigeria poisoned with CQ overdose,
following Trump's endorsement.
Peak Canadia health bodies advise healthworkers
against
its use.
India
bans exports
of HCQ, presumably in order to ensure local supplies for treatment of malaria.
Brazil
Health minister resigns over president's
insistence
on promoting
HCQ..
UK bulk-buying millions of HCQ tablets to avoid shortage
(for treating Lupus etc)
caused by Trump's irresponsible statements.
